Tangential Flow Filtration Market to Reach $3.6 Billion by 2028 with 13.5% CAGR

The global Tangential Flow Filtration Market in terms of revenue was estimated to be worth $1.9 billion in 2023 and is poised to reach $3.6 billion by 2028, growing at a CAGR of 13.5% from 2023 to 2028 according to a new report by MarketsandMarkets™. The TFF market is expected to have a growth rate of 13.5% during 2023-2028. Increasing benefits over normal flow filtration, the introduction of single-use technologies, adoption of gamp guidelines, increasing investment by pharmaceutical companies, growing biopharmaceutical industries are some of the factors that will accelerate the growth of the Tangential Flow Filtration Market in the forecast period.

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In 2022, the systems segment accounted for the largest share of the product segment in the Tangential Flow filtration market.

On the basis of products, the tangential flow filtration market is segmented into systems, membrane filters, and other tff products. In 2022, the systems segment accounted for the largest share of the market and is expected to grow at the highest CAGR during 2023-2028. Tangential filtration systems consist of automated and mechanical filtration systems. These systems provide maximum operational reliability. Some of the benefits associated with these systems include a high retention rate, less consumption of energy, low cost, and reduced cross-contamination risk. With the help of such systems, pharmaceutical companies can achieve the highest quality products. The systems segment is further segmented into single-use and reusable systems. Single-use systems are gaining importance in separation and purification applications. Developments in research techniques and increased demand for more specificity in the filtration process are increasing the adoption of single-use technologies in many small-scale biopharmaceutical processes.

In 2022, the microfiltration segment accounted for the largest share of the technique segment in the Tangential Flow filtration market.

On the basis of technique, the tangential flow filtration market is segmented into microfiltration, ultrafiltration, nanofiltration, and other techniques. In 2022, the microfiltration segment accounted for the largest market share. The filters used in this technique can be in a submerged configuration or a pressure vessel configuration; they can be hollow fibers, flat, sheet, tubular, or spiral. Membrane filtration technique can be used for removing suspended matter (>99%), harmful microorganisms (e.g., bacteria, protozoa, algae, and fungi) (>99%), and PAHs. Also, MF can be implemented to break down emulsions. Microfiltration with hollow-fiber filters finds applications in processes such as clarification, purification of cell broths, separation of cell debris, and separation of macromolecules. This technique is also used for harvesting cells in upstream bioprocessing and for the recovery & purification of biomass during the production of antibiotics. In biotechnology, microfiltration is used for the retention of biomass from fermentation broths. This technique is also used for the removal of natural and synthetic organic matter to reduce the fouling potential.

In 2022, the Asia Pacific region is the fastest-growing region of the Tangential Flow filtration market.

The tangential flow filtration market is divided into five regions including, North America, Europe, Asia Pacific, Latin America and Middle East and Africa. The Asia Pacific market is expected to register the highest CAGR during 2023-2028. Factors responsiblr for the growth includes, unique industry dynamics accompanied by a highly competitive landscape owing to its complex and diverse regulatory landscape and varying pharma industry infrastructures across each country, impacting innovation in each country.

Tangential Flow Filtration Market Dynamics:


  1. Growing advantages of tangential flow filtration over normal flow filtration
  2. Rising R&D spending in pharmaceutical & biotechnology industries
  3. Increasing adoption of single-use technologies
  4. Increased adoption of Good Automated Manufacturing Practice (GAMP)


  1. High capital investments for new production facilities to limit the entry of small players


  1. Emerging economies offer lucrative growth opportunities
  2. Rising therapeutic applications of recombinant proteins


  1. Increased complexities introduced by the interaction of charged excipients and proteins to restrict the market growth
  2. Difficulty in the survival of small players and new entrants

Key Market Players:

Key players in the Market include Merck KGaA (Germany), Danaher Corporation (US), Sartorius AG (Germany), Parker Hannifin Corporation (US), Repligen Corporation (US), Alfa Laval Corporate AB (Sweden), ANDRITZ (Austria), Meissner Filtration Products, Inc. (US), Cole-Parmer Instrument Company, LLC (US), Solaris Biotechnology Srl (Italy), Koch Separation Solutions (US), Sterlitech Corporation US), Synder Filtration, Inc. (US), PendoTECH (US), ARTeSYN Biosolutions (Ireland), Microfilt India Pvt. Ltd. (India), Bionet (Spain), SYSBIOTECH GmbH (Austria), Cobetter Filtration Equipment Co., Ltd. (China), Biotree (India), FORMULATRIX (US), Mantec Technical Ceramics Ltd. (UK), Smartflow Technologies (US), TAMI Industries (France), and SPF Technologies LLC (US).

Recent Developments:

  • In May 2022, Merck KGaA invested over USD 476.7 million to expand its membrane and filtration manufacturing in Ireland.
  • In December 2021, Repligen Corporation acquired Bioflex Solutions, which offers single-use fluid management products.
  • In June 2021, Repligen Corporation signed an agreement to acquire Polymem, which offers hollow-fiber membranes and modules.
  • In March 2021, Pall Corporation acquired Austar Lifesciences Limited. The acquisition aimed to expand the company’s capacity to support single-use technology.

Tangential Flow Filtration Market Advantages:

  • Continuous Processing: TFF allows for continuous filtration, leading to higher productivity and efficiency compared to batch filtration methods.
  • Gentle Processing: TFF handles complex fluids without causing significant shear or damage to the target molecules, ensuring product integrity and bioactivity.
  • Scalability: TFF can be easily scaled up or down to accommodate different process volumes, making it suitable for both laboratory-scale research and large-scale production.
  • Customizability: TFF systems offer modular designs that can be customized and integrated into existing processes, providing operational flexibility.
  • Precise Separation: TFF enables precise separation based on molecule size through the use of different membrane types, pore sizes, and operating parameters.
  • Versatility: TFF can handle a wide range of particle sizes, from large cells to small proteins, making it versatile for various applications.
  • Established Market: TFF is a well-established technology with a mature market, offering a wide range of suppliers, equipment, consumables, and technical expertise.

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Tangential flow filtration market – Report Highlights:

  • Market sizes are updated for the base year 2022 and forecasted from 2023 to 2028.
  • The new edition of the report provides updated financial information till 2022 for each listed company based on the availability of data. This will help in the easy analysis of the present status of profiled companies in terms of their financial strength, profitability, key revenue-generating region/country, and business segment focus in terms of the highest revenue-generating segment.
  • The updated study includes additional market dynamics, technological analysis, indicative pricing, key conferences & events from 2022 to 2023, ecosystem analysis, key stakeholders & buying criteria, supply chain analysis, regulatory information, value chain analysis, patent analysis, the recession impact, and Porter’s five forces analysis of the tangential flow filtration market in the market overview chapter.
  • The revised research study includes the impact of the recession on the tangential flow filtration market.
  • Competitive landscape chapter of the report is updated with the market evaluation framework, market share analysis, revenue share analysis, company evaluation matrix and competitive benchmarking of top players and emerging companies.
  • The new edition of the report provides an updated product portfolio of the companies profiled in the report. Tracking product portfolios of prominent market players helps to analyze the major products in the tangential flow filtration market.
  • The new study includes updated market developments of profiled players from January 2020 to April 2023. Recent developments are helpful to understand market trends and growth strategies adopted by players in the market.

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